Understanding tolerance following immune reconstitution in MS - MS Research Australia

Understanding tolerance following immune reconstitution in MS

Dr Jennifer Massey

St Vincent's Hospital, NSW

| Better treatments | Immunology | Fellowship | 2020 | Investigator Led Research |
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Summary

Dr Jennifer Massey’s research focuses on AHSCT (Autologous Haematopoietic Stem Cell Transplantation) and other therapies that deplete parts of the immune system. She is particularly interested in how the immune system regrows after these therapies. She analyses blood and plasma samples of people with MS prior to, and at specific time points following treatment with AHSCT.

Dr Massey aims to shed light on the underlying cause of MS and how, once depleted, the immune systems regrows or reboots to restore a functional immune system. Specifically, she aims to identify changes in the balance of white blood cells that prevent inflammation and white blood cells that cause inflammation. This will give us key insights into the immune system post-AHSCT, and may help in enhancing understanding of how AHSCT works for MS.

Updated 22 January 2020

Updated: 21 January, 2020

Stages of the research process

Fundamental laboratory
Research

Laboratory research that investigates scientific theories behind the possible causes, disease progression, ways to diagnose and better treat MS.

Lab to clinic timeline: 10+ years
Translational
Research

Research that builds on fundamental scientific research to develop new therapies, medical procedures or diagnostics and advances it closer to the clinic.

Lab to clinic timeline: 5+ years
Clinical Studies
and Clinical Trials

Clinical research is the culmination of fundamental and translational research turning those research discoveries into treatments and interventions for people with MS.

Lab to clinic timeline: 1-5 years

Investigator

Co-investigator

Grant Awarded

  • Postdoctoral Fellowship

Total Funding

  • $180,000

Duration

  • 3 years – starting 2020

Funding Partner

  • MS Angels
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