Developing methods to promote the creation of new myelin in MS

Associate Professor Anthony Don

The University of Sydney, NSW

| A cure via repair and regeneration | Neurobiology | Incubator | 2019 | Investigator Led Research |
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Summary

In MS, the immune system mistakenly attacks the protective layer on nerve cells known as myelin. The removal or damage of myelin is known as demyelination and it results in some of the symptoms observed in people with MS. Current treatments for MS focus on suppressing the immune system and there are yet to be any therapies developed that promote the re-myelination of nerves, which is needed to reverse MS symptoms.

Associate Professor Anthony Don has developed evidence that a naturally occurring signalling chemical in the body known as sphingosine 1-phosphate (S1P), is important for the creation and maintenance of myelin. One of the MS medications, fingolimod (Gilenya), which modulates the immune system, is known to mimic S1P and there is some evidence to suggest that it might also promote remyelination. How it might do this, however, is not yet clear.

This project will aim to determine how S1P might stimulate myelin repair and assess whether this S1P is needed for the body’s natural ability to remyelinate nerves following an MS relapse. The work has direct and immediate significance for MS, as it will clarify whether drugs, such as fingolimod and other similar drugs currently being developed, should be investigated as myelin repair therapies, as well as immune modifying treatments for MS.

Updated: 23 January 2019

Updated: 02 January, 2019

Stages of the research process

Fundamental laboratory
Research

Laboratory research that investigates scientific theories behind the possible causes, disease progression, ways to diagnose and better treat MS.

Lab to clinic timeline: 10+ years
Translational
Research

Research that builds on fundamental scientific research to develop new therapies, medical procedures or diagnostics and advances it closer to the clinic.

Lab to clinic timeline: 5+ years
Clinical Studies
and Clinical Trials

Clinical research is the culmination of fundamental and translational research turning those research discoveries into treatments and interventions for people with MS.

Lab to clinic timeline: 1-5 years

Co-investigator

  • Dr Jonathan David Teo

Grant Awarded

  • Incubator Grant

Total Funding

  • $25,000

Duration

  • 1 year - starting 2019

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