How vitamin D affects the immune system in MS

Dr Wei Yeh

Alfred Health and Monash University, VIC

| Better treatments | Immunology | Scholarship | 2020 | Investigator Led Research |


MS is one of the most common neurological causes of disability among young adults. Living further away from the equator is associated with less exposure to UV from the sun and less vitamin D production, and is also linked to a higher rates of MS. These and other findings support a significant role for vitamin D in the development of MS. Dr Wei Yeh aims to determine the effects that vitamin D has on immune cells in people with MS, and how this is different to people without MS. This will shed further light on the role of vitamin D in MS risk and will help determine ways to prevent the development of MS.

Additionally, Dr Yeh will also investigate factors that might influence the risk of relapses during pregnancy. Previous studies have shown a drop in the risk of relapse during pregnancy. Dr Yeh will use data from MSBase, a large international registry of people with MS, to find factors that predict relapse in pregnancy. These findings will help guide what to do in the clinic to minimise the chances of a relapse during pregnancy.

Updated 22 January 2020

Updated: 21 January, 2020

Stages of the research process

Fundamental laboratory

Laboratory research that investigates scientific theories behind the possible causes, disease progression, ways to diagnose and better treat MS.

Lab to clinic timeline: 10+ years

Research that builds on fundamental scientific research to develop new therapies, medical procedures or diagnostics and advances it closer to the clinic.

Lab to clinic timeline: 5+ years
Clinical Studies
and Clinical Trials

Clinical research is the culmination of fundamental and translational research turning those research discoveries into treatments and interventions for people with MS.

Lab to clinic timeline: 1-5 years


  • Dr Wei Yeh

Grant Awarded

  • Postgraduate Scholarship

Total Funding

  • $42,560


  • 2 years over 2020 - 2021

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