Identifying epigenetic factors associated with MS

Professor Rodney Scott

The University of Newcastle, NSW

| Causes and Prevention | Genetics | Project | 2019 | Investigator Led Research |


Epigenetics is the mechanism used by the body to turn genes on and off in different tissues and is a way of regulating gene activity. Epigenetic mechanisms can also be affected by environmental factors, and may provide the link between genes and the environment in MS. It is a new frontier in MS research that may be involved in the risk of developing MS as well as the severity of disease and an individual’s response to treatments.

This project will examine the level of DNA methylation across the genome (all genes simultaneously) in people at the start of their disease as well as people who have gone on to have severe MS with the aim of identifying new markers associated with disease severity. It is hoped this research will reveal new ways of predicting progression in MS and better treatment strategies for preventing the increase of disability.

Updated: 23 January 2019

Updated: 05 January, 2019

Stages of the research process

Fundamental laboratory

Laboratory research that investigates scientific theories behind the possible causes, disease progression, ways to diagnose and better treat MS.

Lab to clinic timeline: 10+ years

Research that builds on fundamental scientific research to develop new therapies, medical procedures or diagnostics and advances it closer to the clinic.

Lab to clinic timeline: 5+ years
Clinical Studies
and Clinical Trials

Clinical research is the culmination of fundamental and translational research turning those research discoveries into treatments and interventions for people with MS.

Lab to clinic timeline: 1-5 years


Grant Awarded

  • Project Grant

Total Funding

  • $211,000


  • 3 years - starting 2019

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