MS is a disease resulting from damage to the insulation around nerve fibres in the brain and spinal cord, called myelin. It occurs when the body’s own immune system mistakenly identifies myelin as a foreign invader. MS most commonly presents with a relapsing remitting (RRMS) disease course, which is categorised by flare-ups followed by periods of recovery. However, many people with RRMS end up developing secondary progressive MS (SPMS), which is categorised by a steady worsening of symptoms without recovery. A minority of people present with primary progressive MS (PPMS), where there is a steady accumulation of disability right from diagnosis. While many treatments are now available for RRMS, there are few effective therapies for progressive MS that prevent the worsening of disability. This may be because there are different biological processes involved in relapsing and progressive MS. Current therapies generally target cells in the immune system that are thought to directly attack nerve cells. However, a potentially more potent approach is to dampen down the initial stimulation of the immune system. This could be done by having a treatment that mimics the natural signals that dampen down the immune system.
Existing work from this laboratory group has identified some of these signals. They have also found a gene involved in regulating the immune response, found in 40% of Caucasian people with MS, which can increase the likelihood of developing progressive MS.
The aim of this project is to study ways to dampen down the abnormal immune activation, which will hopefully lead to new ways of combatting MS.
Updated 22 January 2020
Updated: 21 January, 2020
Laboratory research that investigates scientific theories behind the possible causes, disease progression, ways to diagnose and better treat MS.
Research that builds on fundamental scientific research to develop new therapies, medical procedures or diagnostics and advances it closer to the clinic.
Clinical research is the culmination of fundamental and translational research turning those research discoveries into treatments and interventions for people with MS.