Investigating antibody-driven inflammation in MS

Dr Stephanie Trend

Telethon Kids Institute, WA

| Better treatments | Immunology | Project | 2020 | Investigator Led Research |
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Summary

MS is a condition where a person's immune system mistakenly attacks the brain and spinal cord. This can cause a range of symptoms and disability.

Why the immune system mistakenly attacks the body is unknown. This project will investigate whether there is any intrinsic differences between immune cell functions in people with MS compared to people without MS. To do this, immune cells will be collected from the blood of people with MS and those without. The team will then determine whether cells from people with MS are more prone to having an inflammatory response compared to those who don’t have MS when they are exposed to antibodies (small proteins produced by the immune system which bind foreign substances that invade the body and activate the immune system). They will also investigate whether people with an early stage of MS have the same responses to antibodies as those with more advanced disease.

Updated 22 January 2020

Updated: 21 January, 2020

Stages of the research process

Fundamental laboratory
Research

Laboratory research that investigates scientific theories behind the possible causes, disease progression, ways to diagnose and better treat MS.

Lab to clinic timeline: 10+ years
Translational
Research

Research that builds on fundamental scientific research to develop new therapies, medical procedures or diagnostics and advances it closer to the clinic.

Lab to clinic timeline: 5+ years
Clinical Studies
and Clinical Trials

Clinical research is the culmination of fundamental and translational research turning those research discoveries into treatments and interventions for people with MS.

Lab to clinic timeline: 1-5 years

Investigator

Grant Awarded

  • Project Grant

Total Funding

  • $170,470

Duration

  • 2 years over 2020 - 2021

Funding Partner

  • McCusker Charitable Foundation
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